Neural Control of Respiratory and Cardiovascular Function
Irene C. Solomon
Assistant Professor
PhD, UC Davis
The overall goal of the research in my laboratory is to understand the mechanisms by which central nervous system (CNS) neurons integrate peripheral and central inputs in respiratory and cardiovascular control. At present, we are investigating CNS sites and neuropharmacological mechanisms mediating hypoxic ventilatory and sympathetic responses. Severe brain hypoxia which may result from numerous cardiovascular and respiratory diseases (e.g., stroke, corpulmonale) results in a shift from respiratory depression excitation (gasping) and an increase in sympathetic output. In the laboratory, we are examining the brainstem sites and neural mechanism(s) responsible for this shift in respiratory patterning as well as the synchronization of the central respiratory cycle with sympathetic activity. The experimental approach in the laboratory involves neuroanatomical mapping electrophysiological recording, and neuropharmacology.
Another focus of research in my laboratory examines reflex and central neural control of the airways.
Relevent Publications:
Solomon, I.C. and T.P. Adamson. Static muscular contraction elicits a pressor reflex in the chicken. Am. J. Physiol. 272:R759-R765, 1997.
Solomon, I.C., N.H. Edelman, and J.A. Neubauer. Hypoxia enhances phrenic nerve activity following disinhibition of neurons in the pre-Bötzinger complex.
Soc. Neurosci. Abst. 22:1596, 1996.
Motekaitis, A.M., I.C. Solomon, and M.P. Kaufman. Blockade of glutamate receptors in CVLM and NTS attenuates airway dilation evoked from parabrachial
region. J. Appl. Physiol. 81:400-407, 1996.
Solomon, I.C., A.M. Motekaitis, M.K.C. Wong, and M.P. Kaufman. NMDA receptors in caudal ventrolateral medulla mediate reflex airway dilation arising from the
hindlimb. J. Appl. Physiol. 77:1697-1704, 1994.